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Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Updated: Oct 18, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
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[Metastatic basal cell carcinoma].

Julie Tastesen Johannessen1, Michael Prangsgaard Møller

  • 1julietastesen@gmail.com.

Ugeskrift for Laeger
|October 1, 2021
PubMed
Summary
This summary is machine-generated.

Metastatic basal cell carcinoma (BCC) is rare, but can spread to lymph nodes. This case report details a neglected BCC that metastasized to axillary lymph nodes, requiring surgical removal.

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Area of Science:

  • Dermatology
  • Oncology

Context:

  • Basal cell carcinoma (BCC) is the most prevalent form of skin cancer.
  • Metastasis from BCC is exceptionally rare, occurring in 0.0028-0.55% of cases.
  • Aggressive histological subtypes, such as infiltrating and morphea forms, have a higher propensity for metastasis.

Purpose:

  • To report a rare case of neglected primary basal cell carcinoma with metastasis.
  • To highlight the potential for BCC metastasis to regional lymph nodes.
  • To describe the management of axillary lymph node metastasis from BCC.

Summary:

  • A case of a neglected primary basal cell carcinoma on the trunk is presented.
  • The BCC metastasized to the ipsilateral axillary lymph nodes.
  • The patient underwent radical axillary lymph node dissection, with no further adjuvant therapy administered.

Impact:

  • This case underscores the importance of early detection and treatment of basal cell carcinoma, even if seemingly benign.
  • It emphasizes that neglected BCCs, regardless of initial presentation, can potentially metastasize.
  • The report contributes to the understanding of rare metastatic patterns of BCC and informs clinical management strategies.