Related Experiment Video

Updated: Oct 18, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

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Meta-Analysis Of Antenatal Depression And Adverse Birth Outcomes In US Populations, 2010-20

Shannon D Simonovich1, Nichole L Nidey2, Amelia R Gavin3

  • 1Shannon D. Simonovich (s.d.simonovich@depaul.edu) is an assistant professor in the School of Nursing, College of Science and Health, DePaul University, in Chicago, Illinois.

Health Affairs (Project Hope)
|October 4, 2021
PubMed

Untreated depression presents a distinct set of risks for pregnancy complications. Past studies have connected antenatal depression with adverse birth outcomes. The purpose of this study was to conduct an updated systematic review and meta-analysis examining the relationship between depression during pregnancy and associated adverse birth outcomes in US populations during the period 2010-20. As a trend, disparities in adverse pregnancy outcomes and maternal morbidities for Black pregnant people compared with those for White pregnant people continue to rise. Addressing mental health conditions during pregnancy has the potential to ameliorate a large and excessive burden on adverse birth outcomes among childbearing people and their offspring. Policy solutions to encourage, mandate, and reimburse universal depression screening during pregnancy are warranted.

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