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Engineering microbial metabolic energy homeostasis for improved bioproduction
Tian Tong1, Xiulai Chen2, Guipeng Hu2
1Hunan Provincial Key Laboratory for Forestry Biotechnology, Central South University of Forestry and Technology, Changsha 410004, China; International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology of Hunan Province, Central South University of Forestry and Technology, Changsha 410004, China.
Biotechnology Advances
|October 5, 2021
Summary
Maintaining microbial metabolic energy (ME) homeostasis is crucial for bioproduction. This review outlines strategies to improve ME supply and reduce consumption, enhancing microbial cell factory efficiency.
Area of Science:
- Biotechnology and Synthetic Biology
- Microbial Physiology
- Metabolic Engineering
Background:
- Metabolic energy (ME) homeostasis is vital for microbial cell factory survival and function.
- Bioproduction often suffers from disrupted ME homeostasis due to inefficient supply and excessive consumption.
- Addressing these ME imbalances is key to improving bioproduction yields.
Purpose of the Study:
- To review strategies for engineering microbial ME homeostasis.
- To provide guidance for enhancing the efficiency of microbial cell factories in bioproduction.
- To highlight the role of biotechnology in optimizing ME balance.
Main Methods:
- Review of existing literature on ME homeostasis in microbial systems.
- Analysis of strategies for reinforcing ME-harvesting systems in autotrophs.
- Examination of methods to enhance ME-supplying pathways in heterotrophs.
- Discussion of techniques to reduce non-essential ME consumption in microbial cells.
Main Results:
- Proposed strategies focus on optimizing ME supply and utilization.
- Reinforcing ME-harvesting in autotrophs and enhancing ME pathways in heterotrophs are key.
- Reducing unnecessary ME consumption can significantly improve cellular efficiency.
- Biotechnological interventions offer a promising route to engineer ME homeostasis.
Conclusions:
- Engineering microbial ME homeostasis is achievable through targeted biotechnological strategies.
- Optimized ME balance is critical for efficient bioproduction using microbial cell factories.
- This review provides a framework for future research in microbial metabolic engineering for bioproduction.
Keywords:
Energy consumptionEnergy supplyMetabolic energy homeostasisMetabolic engineeringMicrobial cell factorySynthetic biologyMore Related Videos
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