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Updated: Oct 17, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Versatile Access to Tetrasubstituted 2-Amidoacroleins through Formal Silylformylation of Ynamides
Stéphane Golling1, Frédéric R Leroux1, Morgan Donnard1
1Université de Strasbourg, CNRS, Université de Haute-Alsace (LIMA UMR 7042), École Européenne de Chimie, Polymères et Matériaux (ECPM), F-67000 Strasbourg, France.
Abstract:
In this paper we are reporting the first regio- and stereoselective silylformylation of ynamides. This reaction is tolerant to a wide range of functional groups around the ynamides. The substitution of CO by an isocyanide makes this reaction safer and more practical than standard silylformylation reactions. It overall represents a versatile and rapid access to various tetrasubstituted 3-silyl-2-amidoacrolein derivatives. The synthetic potential of these new building blocks has been evaluated by performing several postfunctionalization.
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