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Updated: Oct 17, 2025

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
[Update Treatment HPV-16-positive Oropharyngeal Carcinoma]
Andreas Dietz1, Gunnar Wichmann, Susanne Wiegand
1Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Plastische Operationen, Universität Leipzig, Leipzig, Germany.
Background:
Oropharynx carcinoma (OPSCC) is a genetically heterogeneous tumor group with high prognostic diversity due to its worldwide increase in incidence and the association with the human papillomavirus HPV 16, but also chronic tobacco/alcohol consumption.
Objective:
The review attempts to present the current view on therapy and prevention of OPSCC with respect to association with HPV 16.
Material & Methods:
The overview is based on the current relevant literature as well as current studies.
Results & Discussion:
The OPSCC presents itself as a very complex, genetically heterogeneous group of head and neck tumors, which should therefore be considered in detail. The currently contradictory trial situation of retrospective studies versus prospective trials, the current TNM classification (8th edition) and the scarce prospective data arguing for non-inferiority of therapy de-intensification attempts currently admonish to encourage a more conservative treatment.
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