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Updated: Oct 17, 2025

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Liquid Chromatography-Mass Spectrometry for Clinical Metabolomics: An Overview.

Izadora L Furlani¹, Estéfane da Cruz Nunes², Gisele A B Canuto²

¹Núcleo de Pesquisa em Cromatografia (Separare), Department of Chemistry, Federal University of São Carlos, São Carlos, SP, Brazil.

Advances in Experimental Medicine and Biology

|October 10, 2021

Summary

This summary is machine-generated.

Metabolomics, using advanced LC-MS, analyzes metabolites for health insights. This approach aids in understanding diseases, drug development, and personalized medicine through metabolic phenotyping.

Keywords:

Biomarkers Clinical research LC-MS Mass analyzers Metabolomics Sample preparation

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Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS

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Last Updated: Oct 17, 2025

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Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS

Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS

Published on: May 20, 2013

Area of Science:

Biochemistry and Analytical Chemistry
Biomedical Sciences and Clinical Research

Background:

Metabolomics provides comprehensive analysis of metabolites in biological samples.
Advancements in liquid chromatography and mass spectrometry (LC-MS) have significantly accelerated LC-MS-based metabolomics.
Metabolic phenotyping is increasingly used to understand clinical and biological problems.

Purpose of the Study:

To provide an overview of current approaches in LC-MS-based metabolomics.
To highlight the diverse applications of LC-MS-based metabolomics in clinical research.

Main Methods:

Utilizes liquid chromatography and mass spectrometry (LC-MS) for metabolite analysis.
Employs both targeted and untargeted metabolomics strategies.
Focuses on analytical techniques for comprehensive metabolic profiling.

Main Results:

Demonstrates the exponential progress in LC-MS-based metabolomics due to technological evolution.
Highlights the utility of metabolomics in various health and medical fields.
Establishes the role of metabolic phenotyping in understanding complex biological systems.

Conclusions:

LC-MS-based metabolomics is a powerful tool in modern biomedical and clinical research.
Its applications span disease biomarker discovery, drug development, toxicology, and personalized medicine.
Metabolomics offers critical insights for advancing health and medical science.