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Leukemic and Lymphomatous Optic Neuropathy: A Case Series.
Victoria Lee1, Asim V Farooq, Hassan A Shah
1Pritzker School of Medicine (VL), University of Chicago, Chicago, Illinois; and Department of Ophthalmology and Visual Science (AVF, HAS), University of Chicago, Chicago, Illinois.
Summary
Diagnosing and treating optic neuropathy in leukemia and lymphoma patients is challenging, lacking a definitive standard. This study clarifies a multidisciplinary approach for better diagnosis, treatment, and prognosis in these complex cases.
Area of Science:
- Ophthalmology
- Hematology
- Neurology
Background:
- Leukemia and lymphoma can cause optic neuropathy, indicating potential central nervous system involvement.
- Prompt evaluation and treatment are crucial, but a diagnostic and management gold standard is lacking.
Purpose of the Study:
- To review the diagnosis and management of optic neuropathy in leukemia and lymphoma.
- To present illustrative cases and discuss treatment outcomes.
Main Methods:
- A case series and literature review were conducted.
- Two representative cases were selected for detailed discussion of treatment and outcomes.
Main Results:
- Seven cases of optic nerve infiltration by leukemia or lymphoma were reported.
- Treatments included steroids, radiation, systemic chemotherapy, intrathecal chemotherapy, and CAR T-cell therapy.
Conclusions:
- Leukemic and lymphomatous optic neuropathy presents diagnostic and therapeutic challenges.
- A multidisciplinary, individualized approach is recommended for diagnosis, treatment, and prognosis.
