Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.7K
General Transcription Factors01:30

General Transcription Factors

5.9K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.9K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.7K
Transcription Factors02:16

Transcription Factors

79.4K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
79.4K
The Thyroid Gland01:23

The Thyroid Gland

4.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.9K
Master Transcription Regulators02:23

Master Transcription Regulators

7.2K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting TMED4 enhances CD8<sup>+</sup> T cell function and CAR T cell efficacy in solid tumors through the IRE1α-autophagy axis.

Science advances·2026
Same author

Decoding the gut microbiota-immune dialogue: from bidirectional axis to therapeutic applications.

Journal of nanobiotechnology·2026
Same author

CXCR4: A Promising Novel Strategy for Lung Cancer Treatment.

Biomolecules·2026
Same author

The Landscape of SERCA2 in Cardiovascular Diseases: Expression Regulation, Therapeutic Applications, and Emerging Roles.

Biomolecules·2026
Same author

Lactate bridges mesangial cells to the differentiation of follicular helper T cells in lupus nephritis.

Nature communications·2025
Same author

Distribution of gut microbiota across intestinal segments and their impact on human physiological and pathological processes.

Cell & bioscience·2025
Same journal

Resveratrol Mitigates Noise-Induced Cochlear Damage and Delays Hearing Loss in Wistar Rats.

BioMed research international·2026
Same journal

RETRACTION: Green Fabrication of Silver Nanoparticles Using Euphorbia Serpens Kunth Aqueous Extract, their Characterization, and Investigation of its in Vitro Antioxidative, Antimicrobial, Insecticidal, and Cytotoxic Activities.

BioMed research international·2026
Same journal

Predictors of Prolonged Hospital Length of Stay in Patients With Odontogenic Infections in Ghana.

BioMed research international·2026
Same journal

Traditional Chinese Medicine Bone-Setting Techniques Research Progress for the Treatment of Knee Osteoarthritis.

BioMed research international·2026
Same journal

RETRACTION: miR-375 Inhibits the Proliferation and Invasion of Nasopharyngeal Carcinoma Cells by Suppressing PDK1.

BioMed research international·2026
Same journal

Exploring the Therapeutic Potential of Nobiletin in Nonsmall Cell Lung Cancer.

BioMed research international·2026
See all related articles

Related Experiment Video

Updated: Oct 17, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

2.9K

Thyroid Transcription Factor-1: Structure, Expression, Function and Its Relationship with Disease.

Lian Guan1,2, Xu Zhao1,2, Lin Tang1,2

  • 1Key Laboratory of Gene Detection and Therapy of Guizhou Province, Guizhou Zunyi, 563000, China.

Biomed Research International
|October 11, 2021
PubMed
Summary
This summary is machine-generated.

Thyroid transcription factor-1 (TTF-1) is crucial for organ development and function. Its abnormal expression links to human diseases, presenting new diagnostic and therapeutic targets.

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.0K
An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

11.8K

Related Experiment Videos

Last Updated: Oct 17, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

2.9K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.0K
An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

11.8K

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Thyroid transcription factor-1 (TTF-1/NKx2.1) is a key regulator in specific tissues.
  • TTF-1 is vital for the differentiation, development, and maintenance of thyroid, parathyroid, lung, and brain tissues.
  • Aberrant TTF-1 expression is implicated in various human diseases.

Purpose of the Study:

  • To provide a comprehensive review of TTF-1.
  • To elucidate the role of TTF-1 in human disease pathogenesis.
  • To identify future research directions for TTF-1.

Main Methods:

  • Literature review and synthesis of existing research on TTF-1.
  • Analysis of TTF-1 structure, expression, and function.
  • Examination of TTF-1's involvement in clinical diseases.

Main Results:

  • TTF-1 plays a critical role in the development and function of specific organs.
  • Dysregulation of TTF-1 is associated with the pathogenesis of several human diseases.
  • TTF-1 shows potential as a diagnostic and therapeutic target.

Conclusions:

  • A systematic understanding of TTF-1 is essential for advancing research.
  • Further investigation into TTF-1's role can lead to novel prevention and treatment strategies for related diseases.
  • TTF-1 is a promising target for future clinical applications.