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A Novel Spherical Crystallization Method Using Pickering Emulsions.

Jiayuan Wang1, Wenqi Cao1, Jianli Wang1

  • 1School of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China.

Journal of Pharmaceutical Sciences
|October 27, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces Pickering emulsions stabilized by silica nanoparticles for spherical crystallization, reducing surfactant use. This method enhances emulsion stability and produces uniform ibuprofen crystals with faster nucleation.

Keywords:
Depletion attractionPharmaceuticalsPickering emulsionSilica nanoparticlesSpherical crystallization

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Area of Science:

  • Chemical Engineering
  • Crystallization Science
  • Colloid and Surface Chemistry

Background:

  • Spherical crystallization is a key process intensification technique.
  • Surfactants are crucial but pose toxicological concerns, necessitating alternatives.
  • Pickering emulsions offer a potential surfactant-free approach.

Purpose of the Study:

  • To investigate the use of colloidal particle-stabilized Pickering emulsions for spherical crystallization.
  • To eliminate or significantly reduce surfactant usage in crystallization processes.
  • To enhance Pickering emulsion stability using depletion attraction for improved crystallization control.

Main Methods:

  • Preparation of silica nanoparticles to stabilize oil-in-water emulsions.
  • Evaporative crystallization of ibuprofen within stabilized Pickering emulsions.
  • Application of depletion attraction using polyethylene glycol (PEG) and polyvinyl alcohol (PVA) to enhance emulsion stability.
  • Comparison of crystal products obtained using silica nanoparticles versus a conventional non-ionic surfactant (Tween 20).

Main Results:

  • Depletion attraction effectively stabilized Pickering emulsions, enabling high dispersed phase fractions.
  • Mono-dispersed ibuprofen spherical agglomerates were successfully produced.
  • Silica nanoparticles reduced crystallization induction time by promoting heterogeneous nucleation.
  • Steric effects from nanoparticles potentially mitigated secondary agglomeration.

Conclusions:

  • Pickering emulsions stabilized by silica nanoparticles are a viable alternative to surfactant-stabilized systems for spherical crystallization.
  • Depletion attraction significantly improves Pickering emulsion stability and crystallization product morphology.
  • Silica nanoparticles offer advantages in nucleation and agglomeration control, reducing reliance on traditional surfactants.