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Updated: Oct 14, 2025
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Teratoma Generation in the Testis Capsule
Published on: November 7, 2011
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[Adult Prepubertal-Type Teratoma Diagnosed Using Fish Analysis : A Case Report]
Kosuke Mikami1, Satoko Kojima1, Nobuhiko Shimizu1
1The Department of Urology, Teikyo University Chiba Medical Center.
Hinyokika Kiyo. Acta Urologica Japonica
|November 7, 2021
Summary
A rare prepubertal-type testicular teratoma was diagnosed in an adult male. This benign tumor lacks germ cell neoplasia in situ (GCNIS) and does not relapse, differentiating it from aggressive adult teratomas.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Testicular teratomas are classified into prepubertal and postpubertal types.
- Postpubertal teratomas often contain germ cell neoplasia in situ (GCNIS) and are treated as malignant germ cell tumors.
- Prepubertal teratomas are considered benign and have a favorable prognosis.
Observation:
- A 34-year-old man presented with a painless scrotal mass.
- Imaging revealed a 14 mm left scrotal mass with specific characteristics on MRI and CT.
- Serum tumor markers (alpha-fetoprotein, human chorionic gonadotropin-beta) were normal.
Findings:
- Histopathological diagnosis was teratoma without GCNIS.
- Fluorescence in situ hybridization analysis was negative for i(12p).
- The patient was diagnosed with a prepubertal-type testicular teratoma.
Implications:
- Differentiating between prepubertal and postpubertal teratomas is crucial for appropriate clinical management.
- The absence of GCNIS and i(12p) suggests a benign nature and no risk of relapse.
- Accurate diagnosis relies on histopathology and genetic analysis, particularly for i(12p) detection.
