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Updated: Oct 14, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Palladium-Catalyzed Decarbonylative Borylation of Aryl Anhydrides
Wenzhi Zhang1, Fusheng Bie2, Jie Ma1
1College of Chemistry, Chemical Engineering and Materials Science, Zaozhuang University, 1 Bei'an Road, Zaozhuang, Shandong 277160, China.
Abstract:
A palladium-catalyzed base-free decarbonylative borylation of aryl anhydrides has been developed. Catalyst system consisting of Pd(OAc)2/dppb enables readily available aryl anhydrides to be employed as electrophiles for the synthesis of versatile arylboronate esters via O-C(O) bond activation and decarbonylation. This method is characterized by an excellent functional group tolerance and broad substrate scope, using bench stable aryl anhydrides as aryl electrophiles in C-B bond formation. Mechanistic studies and functionalization of late-stage pharmaceutical molecules are disclosed.
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