PASI vs PO-PASI: Patient-Oriented PASI (PO-PASI) is comparable to clinician score PASI

Area of Science:

• Dermatology
• Clinical Research
• Health Informatics

Background:

• Psoriasis Area and Severity Index (PASI) is a standard clinical tool for assessing psoriasis severity.
• Patient-reported outcomes are increasingly important in chronic disease management.
• Validation of digital health tools is crucial for widespread adoption.

Purpose of the Study:

• To validate an online Patient-oriented Psoriasis Area and Severity Index (PO-PASI).
• To compare the PO-PASI with the established Psoriasis Area and Severity Index (PASI).
• To assess the correlation of PO-PASI and PASI with the Dermatology Life Quality Index (DLQI).

Main Methods:

• Comparative observational study involving 97 adult participants with chronic plaque psoriasis.
• Pearson's correlation coefficient and interclass correlation coefficients (ICC) were used for statistical analysis.
• Comparison of PO-PASI and PASI scores against DLQI scores.

Main Results:

• A strong positive linear correlation was found between PO-PASI and PASI (r=0.866, P<0.0001).
• Interrater reliability for PO-PASI compared to PASI was rated as 'good' to 'excellent' (ICC=0.864).
• PO-PASI demonstrated a stronger positive correlation with DLQI than the PASI score.

Conclusions:

• The online PO-PASI is a valid and reliable tool for assessing psoriasis severity in adult patients.
• PO-PASI offers a patient-centered approach that correlates well with clinical assessments and quality of life.
• This digital tool has potential for remote monitoring and management of chronic plaque psoriasis.