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Related Experiment Video

Updated: Oct 13, 2025

Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment
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Published on: November 22, 2024

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Deoxycholic Acid (ATX-101) for Fat Reduction.

Jyoti Gupta, Martin Kassir, George Kroumpouzos

    Journal of Drugs in Dermatology : JDD
    |November 16, 2021
    PubMed
    Summary

    ATX-101, an injectable deoxycholic acid, effectively reduces submental fat with a favorable safety profile. This review covers its use, patient selection, and injection techniques for aesthetic body contouring.

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    Area of Science:

    • Aesthetics
    • Dermatology
    • Pharmacology

    Background:

    • Growing interest in aesthetic treatments for localized fat reduction.
    • Development of both invasive and non-invasive modalities for fat removal.
    • ATX-101 (deoxycholic acid injection) is a key injectable treatment for submental fat.

    Purpose of the Study:

    • To review the pharmacology, mechanism of action, clinical effects, and adverse effects of ATX-101.
    • To provide guidance on patient selection, volume administration, treatment frequency, and injection techniques.
    • To synthesize current literature on ATX-101 for submental fat reduction and potential body contouring applications.

    Main Methods:

    • Literature search of peer-reviewed articles including clinical trials and scientific reviews.
    • Databases searched include MEDLINE and PubMed up to December 2019.
    • Inclusion criteria focused on English-language publications.

    Main Results:

    • ATX-101 is the sole injectable FDA and Health Canada approved drug for moderate to severe submental fat in adults.
    • Demonstrated efficacy in reducing submental fat with a good safety profile.
    • Ongoing trials are exploring its use in body contouring and lipomas.

    Conclusions:

    • ATX-101 is an effective treatment for submental fat reduction.
    • Careful patient selection and precise injection techniques are crucial for optimal outcomes and safety.
    • Further research is investigating broader applications in body contouring.