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Neutrophilic eccrine hidradenitis associated with induction chemotherapy
J E Fitzpatrick1, S D Bennion, O M Reed
1Service of Dermatology, Fitzsimons Army Medical Center, Aurora, CO 80045-6000.
Journal of Cutaneous Pathology
|October 1, 1987
Summary
Neutrophilic eccrine hidradenitis (NEH) can occur in patients with testicular carcinoma, not just leukemia or lymphoma. This condition may result from various chemotherapy agents, not solely cytarabine.
Area of Science:
- Dermatology
- Oncology
- Internal Medicine
Background:
- Neutrophilic eccrine hidradenitis (NEH) is a rare skin reaction.
- Previously, NEH was primarily associated with acute myelogenous leukemia and Hodgkin's lymphoma.
- Cytarabine was suspected as a potential causative chemotherapeutic agent.
Observation:
- Three new cases of NEH associated with induction chemotherapy are presented.
- Two patients had testicular carcinoma, expanding the known associated malignancies.
- Two patients did not receive cytarabine, challenging the sole causative role of this agent.
Findings:
- NEH is not exclusive to hematologic malignancies like acute myelogenous leukemia or Hodgkin's lymphoma.
- Multiple chemotherapeutic agents or combinations can induce NEH.
- Histologic features of NEH demonstrate a spectrum of changes.
Implications:
- NEH should be considered in patients with various cancers receiving induction chemotherapy.
- Clinicians should be aware of NEH as a potential adverse effect of diverse chemotherapy regimens.
- Further research is needed to identify all causative agents and understand NEH pathogenesis.