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Updated: Oct 12, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
Frederick Eyerer1,2, Juli-Anne Gardner1,2, Katherine A Devitt1,2
1University of Vermont Medical Center, Department of Pathology and Laboratory Medicine, Burlington, VT, USA.
Abstract:
Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.
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