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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Mantle cell lymphoma presenting with lethal atraumatic splenic rupture.

Frederick Eyerer^1,2, Juli-Anne Gardner^1,2, Katherine A Devitt^1,2

¹University of Vermont Medical Center, Department of Pathology and Laboratory Medicine, Burlington, VT, USA.

Autopsy & Case Reports

|November 22, 2021

Summary

Mantle cell lymphoma, a cancer with a specific gene fusion, can present aggressively. This case highlights a rare, lethal splenic rupture in a patient with pleomorphic mantle cell lymphoma and variant CCND1 signals.

Keywords:

Cyclin D Lymphoma, Malignant Lymphoma, Mantle-Cell Splenic Rupture

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Area of Science:

Hematology
Oncology
Genetics

Background:

Mantle cell lymphoma (MCL) is a B-cell neoplasm defined by the t(11;14) translocation, leading to CCND1-IGH fusion.
MCL exhibits a wide clinical spectrum, from indolent to highly aggressive disease.
Atraumatic splenic rupture is a rare but potentially fatal complication in hematologic malignancies.

Observation:

A rare case of pleomorphic mantle cell lymphoma (MCL) is presented.
The patient exhibited an unusual finding of three fusion signals, indicative of variant CCND1 gene patterns.
The presentation was marked by a lethal, atraumatic splenic rupture.

Findings:

Variant CCND1 signal patterns in MCL may be associated with aggressive disease phenotypes.
The specific genetic alterations in this pleomorphic MCL case contributed to its aggressive course.
Atraumatic splenic rupture occurred in the context of advanced, aggressive MCL.

Implications:

Understanding variant CCND1 signal patterns is crucial for predicting MCL behavior and prognosis.
This case underscores the importance of considering rare complications like splenic rupture in MCL patients.
Further research into the pathophysiology of splenic rupture in hematologic cancers is warranted.