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Recent advancement of decellularization extracellular matrix for tissue engineering and biomedical application
Jiamin Yang1, Hangyu Dang1, Yi Xu1
1School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Artificial Organs
|December 2, 2021
Summary
Decellularized extracellular matrices (dECMs) offer ideal tissue scaffolds for regenerative medicine. This review covers dECM methods, applications, and future potential in biomedicine.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Decellularized extracellular matrices (dECMs) are ideal scaffolds due to their complex composition, vascular networks, and tissue-specific architecture.
- dECMs provide essential cues for cell homing and are widely used in tissue engineering and regenerative medicine.
Purpose of the Study:
- To review decellularization and sterilization methods for dECM.
- To summarize advancements in recellularization and vascularization techniques.
- To discuss dECM preservation methods for organ banking.
Main Methods:
- Review of decellularization and sterilization protocols.
- Summary of recellularization and vascularization techniques.
- Discussion of dECM preservation methods.
Main Results:
- Biomedical applications of dECM include in vivo transplantation, disease models, drug screening, organoid development, 3D bioprinting, and tissue reconstruction.
- Current research highlights the versatility of dECM biomaterials.
- Challenges and future technologies in dECM development are discussed.
Conclusions:
- Decellularized extracellular matrices (dECMs) show significant promise for broader biomedical applications.
- The field of tissue engineering and regenerative medicine will increasingly leverage dECM technology.
