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Updated: Oct 11, 2025

Basics of Multivariate Analysis in Neuroimaging Data
Published on: July 24, 2010
Introduction to Machine Learning in Neuroimaging
Julius M Kernbach1,2, Jonas Ort3,4, Karlijn Hakvoort3,4
1Neurosurgical Artificial Intelligence Laboratory Aachen (NAILA), RWTH Aachen University Hospital, Aachen, Germany. jkernbach@ukaachen.de.
Abstract:
Advancements in neuroimaging and the availability of large-scale datasets enable the use of more sophisticated machine learning algorithms. In this chapter, we non-exhaustively discuss relevant analytical steps for the analysis of neuroimaging data using machine learning (ML), while the field of radiomics will be addressed separately (c.f., Chap. 18 -Radiomics). Broadly classified into supervised and unsupervised approaches, we discuss the encoding/decoding framework, which is often applied in cognitive neuroscience, and the use of ML for the analysis of unlabeled data using clustering.

