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Updated: Oct 11, 2025
09:57
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
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Poly(disulfide)s: From Synthesis to Drug Delivery.
Ruhe Zhang1, Tianqi Nie2, Yifen Fang3
1Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China.
Biomacromolecules
|December 7, 2021
Summary
Poly(disulfide)s are versatile bioresponsive polymers ideal for drug delivery due to their degradability and responsiveness. This review explores their synthesis, applications, and design strategies for advanced drug delivery systems.
Area of Science:
- Polymer Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Bioresponsive polymers are crucial for drug delivery due to their inherent degradability.
- Poly(disulfide)s, featuring repeating disulfide bonds, offer dynamic, reversible properties.
- These properties enable responsiveness to various stimuli, making them suitable for on-demand drug release.
Purpose of the Study:
- To review the synthesis methodologies of poly(disulfide)s.
- To discuss the diverse applications of poly(disulfide)s in drug delivery.
- To highlight recent advancements and inspire novel applications in the field.
Main Methods:
- Classification of synthesis methods based on monomers: oxidative step-growth polymerization (dithiols), ring-opening polymerization (cyclic disulfides), and polymerization (linear disulfides).
- Discussion of applications including small-molecule and biomacromolecular drug delivery.
- Inclusion of quantum-dot-loaded poly(disulfide) systems for imaging.
Main Results:
- Poly(disulfide)s can be synthesized through various polymerization techniques.
- These polymers demonstrate efficacy in delivering both small and large drug molecules.
- Advanced applications include stimuli-responsive drug release and bioimaging.
Conclusions:
- Poly(disulfide)s represent a promising class of materials for advanced drug delivery systems.
- Their tunable properties allow for precise control over drug release kinetics.
- Further research into design strategies can unlock new therapeutic and diagnostic applications.
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