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Related Experiment Videos

Prostaglandin E2 and fever: a continuing debate.

F Coceani, I Bishai, J Lees

    The Yale Journal of Biology and Medicine
    |March 1, 1986
    PubMed
    Summary
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    Prostaglandin E2 (PGE2) synthesis in the brain increases during fever, supporting its role in thermoregulation. This study confirms PGE2

    Area of Science:

    • Neuroscience
    • Physiology
    • Immunology

    Background:

    • Prostaglandin E2 (PGE2) is implicated as a mediator of fever.
    • Previous studies have presented conflicting evidence regarding PGE2's role in fever.
    • The involvement of other cyclooxygenase products, like thromboxane A2 (TXA2), in pyrogenic responses is unclear.

    Purpose of the Study:

    • To investigate the role of Prostaglandin E2 (PGE2) in fever generation.
    • To determine the temporal relationship between PGE2 synthesis and fever.
    • To differentiate the mechanisms of fever induced by different pyrogens and routes of administration.

    Main Methods:

    • Measurement of brain PGE2 synthesis during experimentally induced fever.
    • Administration of pyrogens (bacterial and leucocytic) via different routes (intravenous and intrathecal).

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  • Investigation of the central nervous system (CNS) sites involved in pyrogen action.

    • Main Results:

    • Brain PGE2 synthesis was confirmed to increase during fever, with kinetics supporting a causal role.
    • Evidence suggests that thromboxane A2 (TXA2) is not involved in pyrogen action.
    • The sequence of events leading to fever depends on the pyrogen type and administration route.
    • Interleukin-1 (IL-1) and endotoxin act on the organum vasculosum laminae terminalis (OVLT) when blood-borne.
    • Endotoxin may also stimulate PGE2 synthesis in cerebral microvasculature.
    • Intrathecal administration of pyrogens leads to diffuse CNS action.

    Conclusions:

    • PGE2 is well-suited to act as an intermediary in fever genesis.
    • Discrepancies in previous findings are likely due to methodological differences.
    • The specific pathways for fever induction vary based on pyrogen and administration route.