Curcumin-Chitosan Nanocomposite Formulation Containing Pongamia pinnata-Mediated Silver Nanoparticles, Wound Pathogen...

Area of Science:

• Nanomedicine and biomaterials science.
• Green synthesis and nanotechnology applications in healthcare.

Background:

• Nanotechnology is integral to modern medical sciences, driving advancements in diagnosis, treatment, and disease prevention.
• Rapid progress in biomaterials and nanomedicine enhances capabilities for illness management.

Purpose of the Study:

• To evaluate the antibacterial, anti-inflammatory, and cytotoxic potential of a green-synthesized silver nanoparticle-curcumin-chitosan nanocomposite (SCCN).
• To assess the efficacy of SCCN against wound pathogenic bacteria.

Main Methods:

• Characterization of silver nanoparticles and SCCN using UV-Vis spectrophotometry, SAED, and TEM.
• Assessment of SCCN's anti-inflammatory, antimicrobial, and cytotoxic activities.
• Evaluation of SCCN-coated clinical silk for antibacterial efficacy.

Main Results:

• SCCN demonstrated significant antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
• The nanocomposite exhibited notable anti-inflammatory effects.
• SCCN proved to be biocompatible and non-toxic.

Conclusions:

• The developed SCCN is an environmentally benign biomaterial with potent antimicrobial and anti-inflammatory properties.
• This nanocomposite offers a safe and effective solution for reducing pathogenic organism effects in wound care.
• SCCN presents a promising, zero-danger material for human and environmental applications.