[Caution over diagnosis of preperimetric glaucoma]

Area of Science:

• Ophthalmology
• Glaucoma Research
• Clinical Diagnosis

Background:

• Preperimetric glaucoma (PPG) represents the initial phase of primary open-angle glaucoma (POAG).
• The diagnostic criteria and clinical validity of PPG remain subjects of ongoing debate.
• Early glaucoma detection is critical for preventing irreversible vision loss.

Purpose of the Study:

• To critically evaluate the diagnostic challenges and clinical significance of preperimetric glaucoma.
• To explore key factors influencing the diagnosis of early-stage glaucoma.
• To advocate for a more standardized and evidence-based approach to PPG diagnosis.

Main Methods:

• Review of clinical significance of intraocular pressure (IOP) measurements.
• Analysis of etiological classifications of primary open-angle glaucoma (POAG).
• Evaluation of follow-up strategies for PPG diagnosis, device accuracy, and genetic factors.

Main Results:

• The diagnosis of PPG requires careful consideration of multiple clinical parameters.
• Intraocular pressure, etiology, follow-up data, diagnostic tools, and genetics are all pertinent to PPG diagnosis.
• Current evidence suggests PPG diagnosis is complex and requires cautious interpretation.

Conclusions:

• Preperimetric glaucoma diagnosis necessitates a comprehensive and meticulous clinical approach.
• Establishing consensus on PPG diagnosis is vital for advancing glaucoma care.
• Improved understanding and diagnosis of PPG can enhance overall glaucoma management strategies.