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Chronic Systemic Inflammation Measured by Bioimpedance Technology Before and After Sleeve Gastrectomy: A Feasibility
Geronikolou S1, Dennis Cokkinos2, Dario Boschiero3
1Biomedical Research Foundation of the Academy of Athens, Clinical, Translational, Experimental Surgery Research Center, Athens, Greece. sgeronik@bioacademy.gr.
Advances in Experimental Medicine and Biology
|January 13, 2022
Summary
Bariatric surgery significantly reduces weight, stress, anxiety, and depression. Advanced bioimpedance technology effectively monitors chronic inflammation and patient recovery post-surgery.
Area of Science:
- Medical Science
- Biomedical Engineering
- Psychiatry
Background:
- Obesity and stress share a bidirectional relationship, impacting mental health.
- Mechanisms linking obesity, stress, and mental health require further investigation.
- Bariatric surgery offers a potential intervention for severe obesity and associated comorbidities.
Purpose of the Study:
- To assess the feasibility of using advanced bioimpedance technology in bariatric patients.
- To evaluate the impact of bariatric surgery on stress, anxiety, and depression levels.
- To explore the relationship between bioimpedance markers, inflammation, and surgical outcomes.
Main Methods:
- Feasibility study involving 18 bariatric patients.
- Utilized Bioimpedance Electrolytic Extracellular Tomography (Tomeex) for advanced body composition analysis.
- Assessed stress, anxiety, and depressive symptoms using validated questionnaires.
- Measured baseline blood markers (hsCRP, glucose) and monitored changes over 6 months post-surgery.
Main Results:
- Significant mean body weight loss of 48.8 kg after 6 months.
- Reduced stress levels (p < 0.05) and a 70% decrease in anxiety and depressive symptoms.
- Observed changes in sensory and autonomic tones (p = 0.003) post-surgery.
- Baseline hsCRP and glucose levels predicted lower abdominal inflammation at 6 months.
Conclusions:
- Bariatric surgery leads to substantial weight loss and significant improvements in mental health.
- Bioimpedance Electrolytic Extracellular Tomography (Tomeex) is a valuable non-invasive tool for monitoring chronic inflammation and recovery post-bariatric surgery.
- Inflammation markers measured by bioimpedance can predict surgical outcomes.
