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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Clinical and Molecular Study of Common Thrombophilia Mutation Prothrombin G20210A
Antonia Angelopoulou1,2,3, Dimitrios Vlachakis4,5, George P Chrousos6
1Unit of Orofacial Genetics, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Background:
One of the most common genetic causes associated with thrombophilia is mutation G20210A of the coagulation factor II (F2) gene.
Materials And Methods:
Data collected from 355 unrelated Greeks examined for the mutation G20210A over a period of two decades were anonymously analyzed.
Results:
The statistical analysis confirmed the importance of F2 G20210A in thrombosis and the significance of a positive family history of thrombosis. An interesting finding was the increased prevalence of G20210A in men with thrombotic events aged >40 years.
Conclusions:
This study highlighted the great value of a positive family history of thrombosis and the importance of testing for this common mutation as a putative prevention strategy and a future biomarker for thrombophilia.
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