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Updated: Oct 6, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
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Aptamer-Based Liquid Biopsy.

Lingling Wu1, Yidi Wang2, Lin Zhu2

  • 1Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

ACS Applied Bio Materials
|January 13, 2022
PubMed
Summary
This summary is machine-generated.

Aptamers offer advanced solutions for liquid biopsy, enabling noninvasive cancer detection and monitoring. This review highlights aptamer applications in isolating and detecting circulating tumor cells (CTCs) and extracellular vesicles (EVs).

Keywords:
aptamercirculating tumor cellsexosomesextracellular vesiclesliquid biopsy

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Liquid biopsy offers noninvasive cancer analysis but faces challenges due to low target concentrations and sample complexity.
  • Aptamers, with their unique properties, are emerging as powerful tools for overcoming these challenges in liquid biopsy.

Purpose of the Study:

  • To review recent advancements in aptamer-based liquid biopsy technologies.
  • To focus on the isolation and detection of circulating tumor cells (CTCs) and extracellular vesicles (EVs).

Main Methods:

  • Summarizing aptamer selection strategies against circulating targets.
  • Reviewing aptamer-based methods for CTC isolation, release, and analysis.
  • Detailing aptamer-mediated signal transduction and amplification for EV detection.

Main Results:

  • Aptamers provide versatile platforms for efficient isolation and sensitive detection of circulating tumor biomarkers.
  • Established aptamers and their characteristics for liquid biopsy applications are comprehensively summarized.
  • Aptamer engineering enables effective strategies for CTC and EV analysis.

Conclusions:

  • Aptamer-based liquid biopsy holds significant promise for cancer diagnosis, prognosis, and personalized therapy.
  • Further development is needed to address existing challenges and fully realize the potential of aptamer applications in liquid biopsy.