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Antioxidant-containing monoolein aqueous dispersions: a preliminary study.
Maddalena Sguizzato1, Markus Drechsler2, Anna Baldisserotto3
1Department of Chemical, Pharmaceutical and Agricultural Sciences (DoCPAS), University of Ferrara, I-44121, Ferrara, Italy.
Drug Delivery and Translational Research
|January 27, 2022
Summary
Monoolein aqueous dispersions (MADs) effectively encapsulate antioxidants like ascorbyl palmitate (AP) and alpha-tocopherol (AT), maintaining their activity and controlling release. These stable formulations show potential for dietary and cosmetic antioxidant delivery.
Area of Science:
- Nanotechnology
- Materials Science
- Biochemistry
Background:
- Antioxidants are crucial for health and cosmetic applications.
- Effective delivery systems are needed to enhance antioxidant stability and bioavailability.
- Monoolein aqueous dispersions (MADs) offer a promising nanocarrier platform.
Purpose of the Study:
- To evaluate monoolein aqueous dispersions (MADs) as delivery systems for ascorbyl palmitate (AP) and alpha-tocopherol (AT).
- To characterize the physical properties and antioxidant activity of MAD formulations.
- To assess the encapsulation efficiency and in vitro release profile of loaded antioxidants.
Main Methods:
- Preparation of MADs using monoolein and poloxamer 407.
- Characterization via Dynamic Light Scattering (PCS) for size and Cryo-Transmission Electron Microscopy (Cryo-TEM) for morphology.
- Antioxidant activity assessed using DPPH assay.
- Encapsulation efficiency and in vitro release studied using Franz cell diffusion.
Main Results:
- MADs exhibited a bimodal size distribution around 200 nm and remained stable for 90 days at 25°C.
- Cryo-TEM revealed distinct morphologies (cubosomes for AP, hexosomes for AT) within the MADs.
- Encapsulation efficiency for both AP and AT exceeded 90%.
- Encapsulated antioxidants retained their activity, with MADs demonstrating controlled release.
Conclusions:
- MAD formulations are stable and capable of high encapsulation of AP and AT.
- The nanostructure of MADs influences the morphology based on the encapsulated antioxidant.
- MADs show potential as effective delivery systems for antioxidant supplementation in dietary and cosmetic applications.
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