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Updated: Oct 5, 2025

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds
Chen Tan1, Seyed Fakhreddin Hosseini2, Seid Mahdi Jafari3,4
1China-Canada Joint Lab of Food Nutrition and Health (Beijing), School of Food and Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China.
Cubosomes and hexosomes are advanced nanocarriers for delivering bioactive compounds in functional foods. These stable systems offer controlled release and protect sensitive ingredients.
Area of Science:
- Food Science and Technology
- Nanotechnology
- Materials Science
Background:
- Cubosomes and hexosomes are biocompatible nanostructured liquid crystalline particles.
- They are increasingly explored as carriers for bioactive compounds in functional foods.
- These systems offer thermodynamic stability and encapsulate diverse substances.
Purpose of the Study:
- To review recent advances in cubosomes and hexosomes for the food industry.
- To focus on their structure, composition, and formation.
- To discuss applications in bioactive delivery and integration with other technologies.
Main Methods:
- Literature review of cubosomes and hexosomes in food applications.
- Analysis of their structural and formation characteristics.
- Exploration of phase transformation factors and advanced integration strategies.
Main Results:
- Cubosomes and hexosomes demonstrate potential for stable encapsulation of hydrophobic and hydrophilic bioactives.
- Their phase behavior is influenced by composition and environmental factors.
- Integration with surface coating, gelation, and polymers enhances their functionality.
Conclusions:
- Cubosomes and hexosomes are promising nanocarriers for functional food ingredients.
- Understanding their formation and phase behavior is key for optimization.
- Combined technologies offer advanced solutions for bioactive delivery.
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