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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
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Redox-Switchable Allosteric Effects in Molecular Clusters.

Benjamin S Mitchell1, Sebastian M Krajewski1, Jonathan A Kephart1

  • 1Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.

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|January 31, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed a redox-switchable allostery mechanism to control molecular cluster assembly. This allows for the creation of stimuli-responsive, atomically precise materials with tunable dimensionality and emissive properties.

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Area of Science:

  • Coordination Chemistry
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Allosteric effects and redox state changes are key molecular recognition mechanisms.
  • Controlling the assembly of molecular clusters into functional materials remains a challenge.

Purpose of the Study:

  • To demonstrate a novel method for regulating molecular cluster assembly using redox-switchable allostery.
  • To create stimuli-responsive, atomically precise inorganic materials with predetermined dimensionality and emissive properties.

Main Methods:

  • Harnessing allosteric effects and redox state changes to create a molecular switch.
  • Utilizing this switch to guide the assembly of Zn3Co6Se8L'6 molecular clusters.
  • Encoding the assembled materials with emissive properties.

Main Results:

  • Selective and reversible regulation of coordination chemistry at a single site on molecular clusters.
  • Assembly of Zn3Co6Se8L'6 clusters into 1- or 2-dimensional materials.
  • Successful encoding of assembled materials with emissive properties.

Conclusions:

  • Redox-switchable allostery provides a powerful tool for programming molecular cluster assembly.
  • This approach enables the creation of novel stimuli-responsive, atomically precise materials.
  • The findings open new avenues for designing advanced functional materials.