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Related Concept Videos

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Related Experiment Video

Updated: Oct 4, 2025

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
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Isolated diastolic hypertension is not associated with endothelial dysfunction.

Yiming Han1, Tatsuya Maruhashi1, Masato Kajikawa2

  • 1Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|February 4, 2022
PubMed
Summary

Isolated diastolic hypertension does not appear to be linked to endothelial dysfunction in individuals not taking blood pressure medication. This finding holds true regardless of which major hypertension guideline is used for diagnosis.

Keywords:
Endothelial functionFlow-mediated vasodilationIsolated diastolic hypertension

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Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Endothelial Function Studies

Background:

  • Hypertension is known to impair endothelial function.
  • The relationship between isolated diastolic hypertension and endothelial dysfunction remains unclear.
  • Existing research has not definitively established whether isolated diastolic hypertension contributes to endothelial dysfunction.

Purpose of the Study:

  • To investigate the association between endothelial function and isolated diastolic hypertension.
  • To evaluate this association using definitions from both the 2017 ACC/AHA and 2018 ESC/ESH hypertension guidelines.
  • To determine if isolated diastolic hypertension is linked to endothelial dysfunction in untreated individuals.

Main Methods:

  • Assessed brachial artery flow-mediated vasodilation (FMD) as a measure of endothelial function.
  • Included subjects without systolic hypertension and not receiving antihypertensive drugs.
  • Analyzed data using multiple logistic regression, adjusting for relevant factors like age and sex.

Main Results:

  • Isolated diastolic hypertension, by either ACC/AHA or ESC/ESH criteria, was not significantly associated with endothelial dysfunction (FMD < 7.0%).
  • Logistic regression showed no significant odds ratio for endothelial dysfunction in subjects with isolated diastolic hypertension.
  • The findings were consistent across both hypertension guideline definitions used in the study.

Conclusions:

  • Isolated diastolic hypertension is not associated with endothelial dysfunction in untreated individuals.
  • This conclusion is supported by analyses using major international hypertension guidelines.
  • Endothelial function appears preserved in individuals with isolated diastolic hypertension who are not on medication.