Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell-mediated immunity in autoimmune thyroid disease.

C L Burek, N R Rose

    Human Pathology
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pathologic changes in the cardiac interstitium of mice infected with encephalomyocarditis virus.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Heritability analysis of IgG4 antibodies in autoimmune thyroid disease.

    Autoimmunity·2014
    Same author

    Hashimoto thyroiditis: clinical and diagnostic criteria.

    Autoimmunity reviews·2014
    Same author

    Susceptibility to autoimmune myocarditis is associated with intrinsic differences in CD4(+) T cells.

    Clinical and experimental immunology·2012
    Same author

    Autoimmunity, infection and adjuvants.

    Lupus·2010
    Same author

    Autoimmunity in coxsackievirus infection.

    Current topics in microbiology and immunology·2008

    Autoimmune responses require specific conditions, including antigen presentation and T cell changes, which are present in the thyroid gland. These factors contribute to the development and pathology of autoimmune thyroid disease.

    Area of Science:

    • Immunology
    • Endocrinology
    • Pathology

    Background:

    • Autoimmune responses necessitate a specific microenvironment for initiation.
    • Key requirements include antigen expression and altered T cell populations.

    Purpose of the Study:

    • To elucidate the conditions required for initiating autoimmune responses.
    • To examine the relevance of these conditions in the context of autoimmune thyroid disease.

    Main Methods:

    • Review of established immunological and pathological criteria for autoimmune initiation.
    • Analysis of the presence of these criteria within the thyroid gland microenvironment.

    Main Results:

    • Antigen expression on target cells and class II antigen on antigen-presenting cells are crucial.

    Related Experiment Videos

  • Alterations in T cell subsets (increased helper/inducer, decreased suppressor) are observed.
  • All identified requirements for autoimmune initiation are present in the thyroid gland.

    • Conclusions:

    • The thyroid gland provides a suitable microenvironment for the initiation of autoimmune responses.
    • Pathological changes in autoimmune thyroid disease result from immune cell interactions, antibody production, or lymphokines.
    • Autoimmune thyroid disease serves as a key model for organ-specific autoimmune endocrinopathies.