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Updated: Oct 4, 2025

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
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Possible Therapeutic Intervention Strategies for COVID-19 by Manipulating the Cellular Proteostasis Network

Mudassar Ali1, Jyotirmoy Rajurkar1, Priyanka Majumder1

  • 1Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Greater Noida, Uttar Pradesh, India.

Advances in Experimental Medicine and Biology
|February 8, 2022
PubMed
Abstract

Insights

Targeting the cellular proteostasis network offers a promising strategy against coronavirus infections like COVID-19. Manipulating these systems may prevent severe disease and aid in developing new therapies.

Area of Science:

  • Cellular Biology
  • Virology
  • Pathogenesis

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, is a global health concern due to high infectivity.
  • Effective treatments and preventive measures for COVID-19 are currently lacking.
  • Understanding host-pathogen interactions is crucial for developing interventions.

Purpose of the Study:

  • To explore the role of the cellular proteostasis network in coronavirus pathogenesis.
  • To investigate the potential of targeting proteostasis pathways for COVID-19 intervention.

Main Methods:

  • Review of scientific literature on proteostasis and viral infections.
  • Analysis of the involvement of Hsp70-Hsp40 chaperone system, Ubiquitin-Proteasome System (UPS), autophagy, and ER-UPR in viral defense and pathogenesis.

Main Results:

  • The proteostasis network, including chaperone systems, UPS, autophagy, and ER-UPR, plays a significant role in host antiviral defense.
  • These cellular pathways are implicated in the pathogenesis of coronavirus infections.
  • Pharmacological manipulation of the proteostasis network can influence the outcome of coronavirus infections.

Conclusions:

  • Targeting the cellular proteostasis network presents a viable therapeutic strategy against COVID-19.
  • Interventions aimed at modulating proteostasis pathways may help prevent COVID-19-related pathologies.
  • Further research into proteostasis network manipulation could lead to novel antiviral therapies.
Keywords:
AutophagyCovid-19ER-UPRHsp70Molecular chaperonesProteostasisSARS-CoV-2

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