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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
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Cancer-associated venous thromboembolism
Alok A Khorana1, Nigel Mackman2, Anna Falanga3,4
1Department of Hematology and Oncology, Taussig Cancer Institute and Case Comprehensive Cancer Center, Cleveland Clinic, Cleveland, OH, USA. khorana@ccf.org.
Nature Reviews. Disease Primers
|February 18, 2022
Summary
Cancer-associated thrombosis, including venous thromboembolism (VTE), worsens survival and is linked to specific cancer types and treatments. Early diagnosis, risk assessment, and anticoagulation are key for managing this serious complication.
Area of Science:
- Oncology
- Hematology
- Vascular Medicine
Background:
- Cancer-associated thrombosis (CAT) significantly impacts patient survival and quality of life.
- Despite advances in cancer care, VTE risk is rising, influenced by cancer type, patient factors, and treatment.
- Tumors can promote thrombosis via altered host systems or direct release of procoagulant proteins.
Purpose of the Study:
- To review the mechanisms, diagnosis, and management of cancer-associated thrombosis.
- To highlight the importance of risk assessment and personalized treatment strategies for VTE in cancer patients.
Main Methods:
- Literature review of cancer-associated thrombosis mechanisms, diagnosis, and treatment.
- Analysis of current VTE risk stratification and prevention strategies.
- Discussion of therapeutic options including anticoagulation and future research directions.
Main Results:
- VTE risk varies by cancer type (e.g., pancreas, stomach, brain tumors) and patient-specific factors.
- Diagnosis relies on clinical assessment, risk scores, and imaging (ultrasonography, CT).
- Anticoagulant therapy is the standard treatment, with personalized approaches essential.
Conclusions:
- Effective management of CAT requires accurate risk assessment, timely diagnosis, and appropriate anticoagulation.
- Personalized treatment considering bleeding risk and patient preferences is crucial for improving outcomes and quality of life.
- Future research should focus on optimizing risk tools, biomarkers, and novel anticoagulants.
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