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Cardiac transplantation.

O H Frazier, D A Cooley

    The Surgical Clinics of North America
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Cardiac transplantation is a proven therapy for end-stage heart disease. The Texas Heart Institute

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    Area of Science:

    • Cardiology
    • Transplantation Medicine
    • Immunology

    Background:

    • Cardiac transplantation has evolved from early experimental studies in 1905 to a recognized treatment for end-stage heart disease.
    • Significant advancements occurred between 1967 and 1968, solidifying its therapeutic potential.
    • The Texas Heart Institute, a leading transplant center, revived its program in 1981.

    Purpose of the Study:

    • To review the outcomes of the cardiac transplant program at the Texas Heart Institute since its re-establishment.
    • To highlight the key factors contributing to the program's success.

    Main Methods:

    • Utilized cyclosporine, an immunosuppressant, for patient management.
    • Implemented meticulous donor selection and patient management protocols.

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  • Focused on detailed surgical procedures and comprehensive postoperative care.
  • Main Results:

    • As of July 17, 1985, 74 heart transplant operations were successfully performed.
    • The program demonstrated consistent application of best practices in all phases of transplantation.

    Conclusions:

    • The Texas Heart Institute's cardiac transplant program has achieved significant success since 1981.
    • Careful attention to donor selection, patient management, surgical technique, and postoperative care are crucial for successful heart transplantation.