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Testicular Dysfunction Among Cancer Survivors
Angel Elenkov1, Aleksander Giwercman1
1Department of Translational Medicine, Lund University, CRC; Jan Waldenströms gata 35, SE 214 28 Malmö, Sweden; Reproductive Medicine Centre, Skane University Hospital, Östra Varvsgatan 11F, SE 205 02 Malmö, Sweden.
Endocrinology and Metabolism Clinics of North America
|February 26, 2022
Summary
Cancer treatments significantly impact male survivors' reproductive health and quality of life. This review covers current evidence, knowledge gaps, and management strategies for testicular function and fertility preservation.
Area of Science:
- Oncology
- Reproductive Endocrinology
- Survivorship Care
Background:
- Increasing cancer survival rates highlight the importance of quality of life (QoL) for young survivors.
- Reproductive health is a key QoL concern for male cancer survivors.
- Cancer and its treatments can affect testicular function, including fertility and androgen production.
Purpose of the Study:
- To summarize current evidence on the impact of cancer and treatments on male reproductive health.
- To identify knowledge gaps and research needs in this area.
- To outline clinical management strategies for reproductive issues in male cancer survivors.
Main Methods:
- Literature review of existing studies on cancer treatment effects on male reproductive function.
- Analysis of data concerning fertility and androgen production.
- Review of clinical guidelines and practices for reproductive care.
Main Results:
- Cancer therapies can impair testicular function, affecting fertility and hormone levels.
- Significant knowledge gaps exist regarding long-term reproductive outcomes and specific treatment effects.
- Current management strategies focus on fertility preservation and hormonal support.
Conclusions:
- Male cancer survivors face significant risks to their reproductive health.
- Further research is needed to fully understand and mitigate these risks.
- Comprehensive pre- and post-therapy management is crucial for optimizing QoL.
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