2D metal carbides and nitrides (MXenes) for sensors and biosensors

MXenes are layered two-dimensional (2D) materials discovered in 2011 (Ti₃C₂X) and are otherwise called 2D transition metal carbides, carbonitrides, and nitrides. These 2D layered materials have been in the limelight for a decade due to their interesting properties such as large surface area, high ion transport, biocompatibility, and low diffusion barrier. Therefore, MXenes are widely preferred by researchers for applications in electronics, sensing, biosensing, electrocatalysis, super-capacitors and fuel cells. There are a number of methods available for the bulk synthesis of MXene-based nanomaterials. In addition, the possibility of structural modification as required and its outstanding surface chemistry offer a fascinating interface for the development of novel biosensors. In this review, we specifically discuss important MXene synthesis routes. Moreover, critical parameters such as surface functionalization that can dictate the mechanical, electronic, magnetic, and optical properties of MXenes are also discussed. Following this, methods available for the surface functionalization and modification strategies of MXenes are also discussed. Furthermore, the emergence of gas, electrochemical, and optical biosensors based on MXenes since its first report is discussed in detail. Finally, future directions of MXenes biosensors for critical applications are discussed.