Phosphate Metabolism: From Physiology to Toxicity

Area of Science:

• Physiology
• Endocrinology
• Nephrology

Background:

• Systemic phosphate homeostasis is a complex process involving multiple organs: intestine, kidney, bone, and parathyroid glands.
• Fibroblast growth factor 23 (FGF23), vitamin D, and parathyroid hormone (PTH) are key endocrine regulators of phosphate balance.
• FGF23, in conjunction with klotho, modulates kidney sodium-phosphate (NaPi) co-transporters, influencing systemic phosphate levels.

Purpose of the Study:

• To provide a comprehensive overview of the physiologic regulation of phosphate homeostasis.
• To elucidate the pathologic dysregulation of phosphate in various health and disease states.
• To serve as a reference for updated information on phosphate metabolism.

Main Methods:

• This work is a curated collection of chapters organized by the editor.
• It synthesizes current knowledge on phosphate metabolism.
• Focuses on the interplay of hormones and organs in phosphate balance.

Main Results:

• The book details the intricate cross-organ communication essential for phosphate homeostasis.
• It explains the molecular mechanisms, including FGF23-klotho signaling, affecting kidney phosphate handling.
• Information on both normal physiological regulation and disease-associated dysregulation is presented.

Conclusions:

• Understanding phosphate homeostasis requires knowledge of endocrine factors and organ crosstalk.
• This volume offers accessible insights into phosphate metabolism for a broad audience.
• It serves as a valuable resource for researchers and clinicians interested in phosphate regulation.