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Updated: Sep 29, 2025

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
Causal Inference: Onward and Upward!
S Listl1, Y Matsuyama2, H Jürges3
1Radboud University Medical Center - Radboud Institute for Health Sciences (RIHS), Department of Dentistry - Quality and Safety of Oral Healthcare, Nijmegen, the Netherlands.
Dental research can improve causal inference by adopting advanced methods like instrumental variables and regression discontinuity designs. Embracing these techniques is crucial for robust oral health evidence.
Area of Science:
- Dental Research
- Epidemiology
- Health Economics
Background:
- The Sveriges Riksbank Prize in Economic Sciences highlights causal inference from natural experiments.
- Economists utilize methods like instrumental variables, regression discontinuity designs, and difference-in-differences for causal inference from observational data.
- Improving causal inference in dental research is increasingly recognized as vital.
Discussion:
- Dental research shows limited application of advanced causal inference methods.
- There's a lack of causal literature addressing key oral health research questions.
- The use of directed acyclic graphs (DAGs) is promoted, but appropriate data-analytic methods for causal inference receive less attention.
- Confusion persists regarding causal language in dental research, mirroring other medical fields.
Key Insights:
- Dental research needs to expand its methodological scope beyond current practices.
- Adopting diverse causal inferential methods is essential for advancing oral health research.
- A more critical and reflective approach to causal inference is necessary.
Outlook:
- Encouraging editors, reviewers, and authors to adopt rigorous causal inference methodologies.
- Fostering a paradigm shift in dental research to strengthen the evidence base for oral health interventions.
- Integrating advanced causal inference techniques to enhance the validity and impact of dental research findings.
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