Related Experiment Video
Updated: Sep 29, 2025
10:33
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
2.8K
[Tubulointerstitial nephritis and uveitis syndrome]
Astrid Thaarup Matthesen1, Jesper Thaarup1, Søren Hagstrøm1
1Børneafdelingen, Aalborg Universitetshospital.
Ugeskrift for Laeger
|March 23, 2022
Summary
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare condition in children. Early diagnosis and consistent monitoring are crucial for managing this complex disorder.
Area of Science:
- Pediatric Nephrology
- Ophthalmology
- Rheumatology
Background:
- Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare autoimmune condition affecting both kidneys and eyes.
- It often presents with delayed or non-simultaneous onset of renal and ocular symptoms, complicating early diagnosis.
Observation:
- This case report details a previously healthy 14-year-old boy diagnosed with TINU syndrome.
- The patient experienced a significant delay between the onset of nephritis and uveitis symptoms.
Findings:
- TINU syndrome is characterized by variable treatment responses and a high likelihood of relapse.
- The case highlights the diagnostic challenges due to the asynchronous presentation of renal and ocular manifestations.
Implications:
- Emphasizes the critical need for long-term, interdisciplinary management involving nephrology, ophthalmology, and rheumatology specialists.
- Recommends routine screening for renal disease in pediatric uveitis patients and ophthalmological evaluation in children with nephritis to ensure timely diagnosis and intervention.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
41
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
41
01:29Acute Kidney Injury II: Pathophysiology
133
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
133
01:26Nephrotic Syndrome II : Assessment and Medical Management
33
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
33
01:25Urinary Tract Infection II: Pathophysiology
70
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
70
01:26Urinary Tract Infection I: Introduction
62
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
62
01:27Acute Pyelonephritis I: Introduction
79
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
79