Related Experiment Video
Updated: Sep 29, 2025
09:16
Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
17.9K
Bioengineered Kidney Models: Methods and Functional Assessments.
Astia Rizki-Safitri1, Tamara Traitteur1, Ryuji Morizane1
1Nephrology Division, Massachusetts General Hospital, Boston, MA 02129, USA.
Function (Oxford, England)
|March 25, 2022
Summary
Bioengineered kidneys show promise for drug testing and regenerative medicine. Functional assessments are crucial for improving these kidney models for clinical applications.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Nephrology
Background:
- Kidney bioengineering is vital for preclinical assays and regenerative medicine.
- Developing improved bioengineered kidneys requires diverse approaches and methods.
- Functional assessments confirm the potential of bioengineered kidneys for translational applications.
Approach:
- A decade of kidney bioengineering research was reviewed, analyzing 84 articles.
- Studies were categorized into five main approaches: de-/recellularization, cell reaggregation, organoids, scaffolds, and kidney-on-a-chip.
- Physiological assessments included filtration, tubular transport, hormone production, and nephrotoxicity.
Key Points:
- Bioengineered kidney models have advanced from simple cultures to complex multicellular systems.
- Only approximately 50% of reviewed studies included functional assessments.
- Cell composition and organization significantly impact the utility of physiological assessments.
Conclusions:
- Functional assessments are critical for advancing bioengineered kidney models.
- Integrating recent technologies with physiological assessments can enhance kidney repair and refunctioning.
- Improved bioengineered kidneys hold significant potential for treating kidney diseases.
