Reverse Transposition - a New Surgical Model for the Study the Role of Ileum in Glucose Metabolism

We studied the possibility of reverse transposition of the small intestine and its effect on glucose metabolism. The reverse transposition model proposed by us consists in a 180° turn of the small intestine after transection and antiperistaltic transposition of the entire intestinal tube. To this end, outbred white rats underwent reverse transposition of the small intestine, sham-operated rats served as the control. Both groups were monitored for body weight and blood glucose levels at fast and after oral glucose tolerance test. The groups did not differ by the duration of surgery, body weight, and blood glucose levels at fast and after glucose tolerance test. The reverse transposition technique proposed by us is reproducible, the anatomical changes lead to early contact of the chyme with the terminal portion of the small intestine, which can modulate absorption of nutrients and the release of ileal hormones (incretins) affecting glucose metabolism.