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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Editorial Commentary: Routine Medical Thromboprophylaxis Following Knee Arthroscopy Has Low Utility-If Any.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026

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Editorial Commentary: Various Medial Patellofemoral Reconstructions Appear Equally Efficacious. But Don't Forget About Medial Retinacular Imbrication for Traumatic Recurrent Patellar Dislocation.

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Editorial Commentary: Tranexamic Acid Shown to Not Inhibit Healing Following Rotator Cuff Repair in Rats.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2024

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Related Experiment Video

Updated: Jul 19, 2026

$Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus$

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Editorial Commentary: Subacromial Bursa May Possess Mesenchymal Progenitor Cells.

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association

|April 4, 2022

Summary

Subacromial bursa tissue contains mesenchymal progenitor cells, important for healing rotator cuff tears. Routine removal of this bursa during surgery may hinder healing and should be reconsidered.

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Isolation of Chondrocytes and Chondroprogenitors Using Fibronectin Adhesion and Migratory Assay

Published on: October 4, 2024

Area of Science:

Orthopedic Surgery
Regenerative Medicine
Cell Biology

Background:

Mesenchymal progenitor cells (MPCs) are crucial for tissue repair and regeneration.
Rotator cuff tears often involve surgical intervention, including arthroscopy.
Subacromial bursectomy is a common procedure during rotator cuff repair surgery.

Discussion:

The presence of MPCs in subacromial bursal tissue suggests a potential role in rotator cuff healing.
Routine excision of the subacromial bursa may inadvertently remove a source of regenerative cells.
This finding challenges the standard practice of complete subacromial bursectomy.

Key Insights:

Subacromial bursal tissue harbors mesenchymal progenitor cells.
These cells may contribute to the healing process following rotator cuff repair.
The therapeutic harvesting of these cells is currently not feasible but their presence is significant.

Outlook:

Future research should investigate the functional role of bursal MPCs in rotator cuff healing.
Clinical guidelines for rotator cuff repair may need revision regarding subacromial bursa management.
Optimizing the preservation of non-diseased bursal tissue could enhance surgical outcomes.