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The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
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Updated: Sep 28, 2025

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Is There a Relationship Between Overactive Bladder and Sexual Dysfunction in Women With Multiple Sclerosis?

Frédérique Le Breton1, Camille Chesnel1, Philippe Lagnau1

  • 1Clinical Research Group in Neurourology (GREEN), GRC 01, APHP, Sorbonne Universities. Service of Neurourology. Tenon Hospital. Paris. France.

The Journal of Sexual Medicine
|April 4, 2022
PubMed
Summary

Sexual dysfunction affects 74% of women with Multiple Sclerosis (MS), even those with mild physical impairment. Overactive bladder is an independent predictor of sexual dysfunction in these women, alongside depression.

Keywords:
Detrusor overactivityFemaleMultiple SclerosisOveractive bladderSexual activitySexual disordersSexual dysfunctionWomen

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Area of Science:

  • Neurology
  • Urology
  • Sexual Medicine

Background:

  • Lower urinary tract symptoms (LUTS) and sexual dysfunction (SD) significantly impact the quality of life for women with Multiple Sclerosis (MS).
  • Understanding the interplay between urinary issues and sexual health is crucial for comprehensive patient care in MS.

Purpose of the Study:

  • To investigate the relationship between sexual dysfunction (SD) and overactive bladder (OAB) in women diagnosed with Multiple Sclerosis (MS).
  • To identify predictors of sexual dysfunction in female MS patients.

Main Methods:

  • 89 female MS patients with LUTS were evaluated for SD using the Female Sexual Function Index (FSFI).
  • Participants completed questionnaires for urinary symptoms (USP), anxiety/depression (HAD A/D), and neurological impairment (EDSS).
  • Statistical analyses, including univariate and multivariate logistic regression, were performed to determine predictors of SD.

Main Results:

  • Sexual dysfunction (FSFI<26.55) was prevalent, affecting 74% of women with MS, irrespective of physical disability level (EDSS<5).
  • Overactive bladder emerged as an independent predictor of sexual dysfunction (aOR 0.03 [CI 0,0.98]).
  • Sexual dysfunction was strongly associated with depression (P < .01) but not with stress incontinence, voiding dysfunction, urinary retention, detrusor overactivity, or mobility impairment.

Conclusions:

  • Sexual dysfunction is highly prevalent in women with MS and warrants clinical assessment alongside urinary disorders.
  • Overactive bladder and depression are significant factors associated with sexual dysfunction in women with MS.
  • The findings highlight the need for integrated management strategies addressing both urinary and psychological aspects of health in MS patients.