Is There a Relationship Between Overactive Bladder and Sexual Dysfunction in Women With Multiple Sclerosis?

Area of Science:

• Neurology
• Urology
• Sexual Medicine

Background:

• Lower urinary tract symptoms (LUTS) and sexual dysfunction (SD) significantly impact the quality of life for women with Multiple Sclerosis (MS).
• Understanding the interplay between urinary issues and sexual health is crucial for comprehensive patient care in MS.

Purpose of the Study:

• To investigate the relationship between sexual dysfunction (SD) and overactive bladder (OAB) in women diagnosed with Multiple Sclerosis (MS).
• To identify predictors of sexual dysfunction in female MS patients.

Main Methods:

• 89 female MS patients with LUTS were evaluated for SD using the Female Sexual Function Index (FSFI).
• Participants completed questionnaires for urinary symptoms (USP), anxiety/depression (HAD A/D), and neurological impairment (EDSS).
• Statistical analyses, including univariate and multivariate logistic regression, were performed to determine predictors of SD.

Main Results:

• Sexual dysfunction (FSFI<26.55) was prevalent, affecting 74% of women with MS, irrespective of physical disability level (EDSS<5).
• Overactive bladder emerged as an independent predictor of sexual dysfunction (aOR 0.03 [CI 0,0.98]).
• Sexual dysfunction was strongly associated with depression (P < .01) but not with stress incontinence, voiding dysfunction, urinary retention, detrusor overactivity, or mobility impairment.

Conclusions:

• Sexual dysfunction is highly prevalent in women with MS and warrants clinical assessment alongside urinary disorders.
• Overactive bladder and depression are significant factors associated with sexual dysfunction in women with MS.
• The findings highlight the need for integrated management strategies addressing both urinary and psychological aspects of health in MS patients.