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Loratadine
Najla AlMasoud1, Ahmed H Bakheit2, Munif Farhan M Alshammari3
1Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Summary
Loratadine is a long-acting antihistamine used for allergies like rhinitis and urticaria. This review details its properties, analysis methods, and clinical applications, including mechanism of action and ADME profiles.
Area of Science:
- Pharmacology
- Medicinal Chemistry
- Analytical Chemistry
Background:
- Loratadine is a widely used, long-acting antihistamine for allergic diseases.
- It exhibits limited selectivity for peripheral H1 receptors.
- Key allergic conditions managed include rhinitis, chronic urticaria, and asthma.
Purpose of the Study:
- To provide a comprehensive review of loratadine.
- To detail its chemical description, physicochemical properties, and analytical methodologies.
- To cover its clinical applications, including dosage, ADME, and mechanism of action.
Main Methods:
- Literature review of loratadine's properties and applications.
- Analysis of physicochemical characteristics (pKa, solubility, X-ray diffraction).
- Spectroscopic identification (FTIR, NMR, Mass Spectrometry) and various analytical techniques (compendial, titrimetric, electrochemical, chromatographic, capillary electrophoretic).
Main Results:
- Detailed description of loratadine including names, formulae, elemental composition, and preparation.
- Characterization of physicochemical properties and structural confirmation using advanced spectroscopic methods.
- Comprehensive overview of analytical methods and clinical data, including ADME and mechanism of action.
Conclusions:
- Loratadine is a well-characterized antihistamine with established therapeutic uses.
- A thorough understanding of its properties and analysis is crucial for its effective application.
- This review consolidates essential information for researchers and clinicians.
Keywords:
Antihistamine drugsClinical applicationsCompendial methodLoratadineMethods of analysisNMRPhysical characteristicsStabilitySynthesis methodsThermal techniques of analysisMore Related Videos
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