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Risk assessment of hepatitis E transmission through tissue allografts

Rafael Villalba1, Vicente Mirabet2

  • 1Center for Blood Transfusion, Tissues and Cells, Córdoba 14004, Spain.

World Journal of Gastrointestinal Pathophysiology
|April 18, 2022
PubMed

Insights

Hepatitis E virus (HEV) can spread through organ transplants. While no HEV transmission cases via cell and tissue allografts were found, screening donors is crucial for preventing HEV spread.

Area of Science:

  • Virology
  • Infectious Diseases
  • Transplantation Immunology

Background:

  • Hepatitis E virus (HEV) genotypes 3 and 4 are linked to zoonotic transmission in developed nations.
  • HEV is a primary cause of acute hepatitis globally.
  • Blood transfusion and organ transplantation are known routes of HEV infection.

Purpose of the Study:

  • To review the risk of HEV transmission via cell and tissue allografts.
  • To identify measures for controlling HEV transmission in allograft procedures.

Main Methods:

  • Literature review on HEV transmission through allografts.
  • Analysis of donor screening and tissue processing protocols.

Main Results:

  • No documented cases of HEV transmission through cell and tissue allografts were identified.
  • Geographical and behavioral data can inform donor risk assessment for HEV.

Conclusions:

  • While no HEV transmission via allografts was found, proactive screening is recommended based on donor profiles.
  • Implementing donor screening and optimized tissue processing can mitigate HEV transmission risks.
Keywords:
Bioburden reductionDisease transmissionDonor screeningHepatitis ERisk assessmentTissue allograft

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