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Computational Fontan Analysis: Preserving Accuracy While Expediting Workflow.

Xiaolong Liu1,2, Seda Aslan1,2, Byeol Kim1,2

  • 1Department of Mechanical Engineering, 1466Johns Hopkins University, Baltimore, MD, USA.

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Summary
This summary is machine-generated.

Computational fluid dynamics (CFD) simulations for Fontan operation hemodynamics require careful mesh selection for accurate hepatic flow distribution prediction. In vitro validation confirms CFD

Keywords:
flow dynamicspatient specific modelvirtual surgical planning

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Computational Fluid Dynamics

Background:

  • Fontan operation outcomes are linked to cavopulmonary pathway geometry.
  • Computational fluid dynamics (CFD) simulations aid in exploring surgical options.
  • Accurate hemodynamic prediction is crucial for optimizing Fontan surgery.

Purpose of the Study:

  • To systematically validate CFD simulation accuracy for Fontan hemodynamics.
  • To investigate the impact of mesh size and numerical solvers on CFD predictions.
  • To compare CFD results with a novel in vitro flow loop setup.

Main Methods:

  • Performed CFD simulations on 10 patient-specific Fontan models.
  • Compared CFD-derived indexed power loss (iPL) and hepatic flow distribution (HFD) with in vitro measurements.
  • Utilized a novel in vitro flow loop with 3D printed models, pressure sensors, and microparticle tracking.

Main Results:

  • CFD mesh size significantly affected HFD (P=.0002) but not iPL (P=.069).
  • Numerical solvers showed no significant impact on iPL (P=.50) or HFD (P=.55).
  • Transient solvers with finer meshes required substantially more computational time for similar results.

Conclusions:

  • CFD predictions for Fontan planning can be validated using in vitro flow loops.
  • Mesh size, model complexity, and flow competition influence CFD prediction accuracy.
  • Optimized CFD parameters are essential for reliable Fontan surgery planning.