Prognostic Value of a Novel Parameter in Patients with Infective Endocarditis

Area of Science:

• Cardiology
• Infectious Diseases
• Medical Diagnostics

Background:

• Infective endocarditis (IE) is associated with high mortality and poor prognosis.
• Predictive markers for in-hospital mortality in IE patients are crucial for clinical management.

Purpose of the Study:

• To evaluate the predictive value of the lactate dehydrogenase (LDH)/lymphocyte ratio (L-LWR) for in-hospital mortality in IE patients.
• To compare the efficacy of L-LWR with the LDH/lymphocyte percentage (L-LWR) in predicting outcomes.

Main Methods:

• Retrospective analysis of medical records from 147 IE patients (January 2017 - December 2019).
• Selection of admission indexes for statistical analysis.
• Comparison of L-LWR and LDH/lymphocyte levels between patients with and without adverse events.

Main Results:

• IE patients without adverse events showed significantly higher LDH/lymphocyte levels and lower L-LWR.
• L-LWR remained an independent predictor of mortality after adjustments (OR: 4.558, P=0.014).
• L-LWR demonstrated high predictive accuracy (AUC: 0.780) with good sensitivity (81.89%) and specificity (65.00%) at a cutoff of 34.

Conclusions:

• L-LWR is a reliable, cost-effective, and easily applicable prognostic marker for in-hospital mortality in IE.
• The L-LWR shows good performance and independence in predicting outcomes for patients with infective endocarditis.