Inadequate Oxygen Delivery Dose and Major Adverse Events in Critically Ill Children With Sepsis

Area of Science:

• Pediatric Critical Care Medicine
• Hemodynamics
• Sepsis Pathophysiology

Background:

• Inadequate oxygen delivery (IDo2) index assesses systemic oxygen delivery but its role in pediatric sepsis is unclear.
• Sepsis is a leading cause of mortality in critically ill children, necessitating improved monitoring tools.

Purpose of the Study:

• To investigate the association between IDo2 dose and adverse events, illness severity, and outcomes in critically ill children with sepsis.
• To determine if IDo2 monitoring can predict adverse events in pediatric sepsis.

Main Methods:

• Retrospective analysis of clinical and IDo2 data from 102 critically ill children with sepsis.
• Statistical analysis included descriptive, nonparametric, odds ratio, and correlational methods.

Main Results:

• Elevated IDo2 doses were significantly linked to major adverse events across multiple time intervals (0-48 hours).
• Patients with IDo2 doses at or above the 80th percentile (0-12 hours) had substantially higher odds of adverse events (OR, 23.6).
• IDo2 dose correlated significantly with illness severity scores (PELOD-2), vasoactive-inotropic support, ventilation duration, ICU stay, and age.

Conclusions:

• Routine IDo2 monitoring in critically ill children with sepsis can identify those at highest risk for adverse events.
• Early identification of high-risk patients through IDo2 monitoring may facilitate timely interventions to improve outcomes.