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Immediate reconstruction of segmental mandibular defects via tissue engineering
Robert O Weiss1, Patrick E Wong1, Likith V Reddy1
1Department of Oral and Maxillofacial Surgery, Baylor University Medical Center and Texas A&M College of Dentistry, Dallas, Texas.
Proceedings (Baylor University. Medical Center)
|May 6, 2022
Summary
Tissue engineering offers a promising alternative for reconstructing large jaw defects caused by ameloblastomas. This approach, using bone morphogenetic protein-2 (rhBMP-2), bone marrow aspirate concentrate, and bone chips, led to satisfactory healing in two patients.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Ameloblastomas are benign, locally invasive odontogenic tumors, frequently occurring in the posterior mandible.
- Large ameloblastoma defects (>6 cm) traditionally require free-flap or iliac crest autogenous grafts for reconstruction.
- Untreated lesions can cause significant deformity and morbidity.
Observation:
- Two cases of large (>6 cm) mandibular segmental resection due to ameloblastoma were presented.
- Immediate reconstruction utilized a tissue-engineering protocol involving bone morphogenetic protein-2 (rhBMP-2), bone marrow aspirate concentrate, and cortical bone chips.
Findings:
- Both patients experienced uneventful postoperative courses and satisfactory healing.
- The tissue-engineering protocol successfully restored bone volume, facial contour, and functionality.
- This method demonstrated a decrease in surgical risks, hospital stay, and postoperative morbidity.
Implications:
- Tissue engineering presents a viable alternative to traditional grafting methods for large jaw defects.
- This approach holds potential for improved patient outcomes in ameloblastoma reconstruction.
- Advances in regenerative medicine are transforming reconstructive surgery in the maxillofacial region.
