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Updated: Sep 24, 2025

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Pearls and Pitfalls of 18FDG-PET Head and Neck Imaging
Randy Yeh1, Ahmad Amer2, Jason Michael Johnson3
1Department of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Abstract:
18FDG-PET plays an important role in cancer imaging. However, there are certain challenges with interpreting head and neck 18FDG-PET. In this article, examples of technical issues that can undermine the interpretation of the scans, normal physiologic activity that can mimic lesions or obscure lesions, and causes of false positives and false negatives on posttreatment cancer imaging are discussed. In addition, suggestions for addressing potential pitfalls on head and neck 18FDG-PET are highlighted.
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