Quantifying disease-specific symptom improvement after parathyroid and thyroid surgery using patient-reported outcome...

Area of Science:

• Endocrine Surgery
• Surgical Outcomes
• Patient-Reported Outcomes

Background:

• The Patient-Reported Outcome Measures for Parathyroid and Thyroid Disease (PROMPT) is a 30-question validated survey.
• PROMPT assesses symptoms on a 0-100 scale.
• This study utilized PROMPT to evaluate symptom changes in patients undergoing parathyroidectomy or thyroidectomy.

Purpose of the Study:

• To assess symptom improvement in patients undergoing thyroidectomy and parathyroidectomy using the PROMPT survey.
• To evaluate the clinical effectiveness of these endocrine surgeries in alleviating patient-reported symptoms.
• To explore the utility of PROMPT as a standardized metric for quality of life assessment in endocrine surgery.

Main Methods:

• A single-center prospective study was conducted.
• The PROMPT survey was administered preoperatively and approximately 6 months postoperatively.
• A total of 144 patients (71 parathyroidectomy, 73 thyroidectomy) completed both assessments.

Main Results:

• Parathyroidectomy patients showed significant improvements in all hyperparathyroidism domains (38.2-28.3, p < 0.001).
• Thyroidectomy patients reported improvement in compressive symptoms (25.6-16.5, p < 0.001).
• Improvements were observed regardless of preoperative calcium and parathyroid hormone levels for parathyroidectomy patients.

Conclusions:

• PROMPT objectively demonstrates the clinical effectiveness of parathyroidectomy and thyroidectomy.
• These surgeries significantly alleviate subjective patient symptoms.
• PROMPT shows promise as a standardized metric for assessing quality of life improvements in endocrine surgery.